Forwarded message:

From: John Spence <spence@asu.edu>
To: jacobsen@chemistry.harvard.edu <jacobsen@chemistry.harvard.edu>, alan@aspuru.com <alan@aspuru.com>, cohen@chemistry.harvard.edu <cohen@chemistry.harvard.edu>, heller@physics.harvard.edu <heller@physics.harvard.edu>, xie@chemistry.harvard.edu <xie@chemistry.harvard.edu>, zhuang@chemistry.harvard.edu <zhuang@chemistry.harvard.edu>, whitesides george <gwhitesides@gmwgroup.harvard.edu>, Shakhnovich@chemistry.harvard.edu <Shakhnovich@chemistry.harvard.edu>, hbach@chemistry.harvard.edu <hbach@chemistry.harvard.edu>, myers@chemistry.harvard.edu <myers@chemistry.harvard.edu>, stuart_schreiber@harvard.edu <stuart_schreiber@harvard.edu>, saghatelian@chemistry.harvard.edu <saghatelian@chemistry.harvard.edu>, cml@cmliris.harvard.edu <cml@cmliris.harvard.edu>, dnocera@fas.harvard.edu <dnocera@fas.harvard.edu>
Cc: David Bell <dcb@seas.harvard.edu>
Date: Sunday, March 31, 2013, 2:26:59 PM
Subject: Molecular Movies with the SLAC X-ray laser. GPCRs and Photosynthesis. April 19

Dear Colleagues,  

  I've been asked to give a talk in Applied Physics on April 19, however this biophysics project may also be relevant to people in  your department. I've be grateful if you would bring it to the attention of interested students and postdocs.

regards and thanks,

John

      Molecular movies from the first X-ray laser.

Harvard Applied Physics, April 19, 2013, 

  John C. H. Spence*  Physics, ASU and LBNL.

       spence@asu.edu

   Snapshot X-ray diffraction from the first hard X-ray laser near Stanford (the LCLS) has provided time-resolved atomic-resolution images of the molecular machine in all green plants which splits water to create the oxygen we breathe, and digests CO2. I'll describe the single-file synchronized submicron droplet beam we use to run molecules across the pulsed laser, and how we image protein molecules important in disease (GPCRs, membrane proteins, 2D crystals, an enzyme drug target for sleeping sickness),  use femtosecond pulses to outrun radiation damage, and unscramble orientational disorder from randomly oriented molecules in solution without modeling, using angular correlation functions. I'll describe how this coherent radiation provides new solutions to the phase problem for nanocrystals. 

The project has been ranked one of the top ten breakthroughs of 2012 by Science journal.

*And many others - see  our review (attached) Spence, Weierstall and Chapman:   Rev Mod Phys. 75, 102601 (2012).

A conference on X-ray lasers for biology will be held at the Royal Society in London from October 14 - you are most welcome to attend.

 Regent's Prof John C.H. Spence ASU Physics/LBNL
http://www.public.asu.edu/~jspence/
https://sites.google.com/a/lbl.gov/biology-with-fels/