Hello Becky, The syllabus you sent me takes an abrupt departure from the Gregorian calendar on March 10, 2005. I placed the corrected syllabus below at http://www.courses.fas.harvard.edu/~mcb195/lectures Sincerely, Jeremy Introduction Thursday, February 3 - In which we meet the mysterious prions and analyse their propensity for polymerization Marc Kirschner and Jeremy Gunawardena Dynamical-systems Tuesday 8 Feb - In which we encounter wild dynamical systems and explore their state spaces. Jeremy Gunawardena Linear-systems Thursday 10 Feb - In which we learn how to tame linear systems and determine their stabilities. Jeremy Gunawardena Oscillations Tuesday 15 Feb - In which we go round in circles. Jeremy Gunawardena Ultrasensitivity Thursday 17 Feb - In which we come to appreciate the virtues of sigmoidality. Jeremy Gunawardena Homeostasis Tuesday 22 Feb - In which we learn how best to remain equable in the face of adversity. Jeremy Gunawardena Molecular-circuits-I Thursday 24 Feb - The behavior of molecular circuits I. Dynamics of regulatory circuits in gene expression and development In which small molecules make big decisions. Walter Fontana Molecular-circuits-II Tuesday 1 March - The behavior of molecular circuits II. The topology of the possible: robustness, neutrality and evolvability In which we ponder on how evolution goes from here to there. Walter Fontana Networks-I Thursday 3 March - Networks: the properties of graphs In which we shall see that being connected is everything Walter Fontana Networks-II Tuesday 8 March - Network motifs and their significance In which math helps us to look at things we cannot look at. Walter Fontana Randomness Thursday 10 March - Randomness In which we toss a coin or two Walter Fontana Stochasticity Tuesday 15 March - Stochasticity in molecular decision processes In which we learn that nothing in life is certain Walter Fontana Searching-space-I Thursday 17 March - Searching space I. In which we consider how non-equilibrium dynamics gives polymers novel properties. Marc Kirschner Searching-space-II Tuesday 22 March - Searching space II The surprising similarities among the strategies used by ants, neurons and microtubules. Marc Kirschner Breaking-symmetry Thursday 24 March - In which we discuss how a homogeneous state can give rise to heterogeneity Marc Kirschner Spatial-patterning-I Tuesday 5 April - Spatial patterning I. Finding the middle, and further subdivisions. Marc Kirschner Spatial-patterning-II Thursday 7 April - Spatial patterning II. In which we consider the roles of induction and feedback in the development of robust patterns. Marc Kirschner The-role-of-evolution Tue 12 April - In which we discuss why things are the way they are. Marc Kirschner Bacterial-chemotaxis-I Thursday 14 April - In which we consider the problem faced by a small prokaryote in sensing a gradient, and learn how time helps. Lew Cantley Bacterial-chemotaxis-II Tuesday April 19 - In which the small prokaryote now faces a wide range of different concentration gradients: the role of adaptation. Lew Cantley Dictostelium-discoideum-chemotaxis-I Thursday 21 April - In which spatial and temporal sensing are invoked to explain eukaryotic directional motility. Lew Cantley Dictostelium-discoideum-chemotaxis-II Tuesday 26 April - In which we discover how spatial sensing is enhanced via feedback regulation. Lew Cantley Directional-motility-in-mammalian-cells Thursday 28 April - In which the mechanisms used by mammalian cells to achieve directional motility are elucidated. Lew Cantley Summary-of-motility Tuesday 3 May - In which all becomes clear, if not simple. Lew Cantley The-future-of-systems-biology Thursday 5 May - The future of systems biology. Marc Kirschner