Please see below for a series of talks that may be of interest to the HQI community.
________________________________
From: Davis, Jolanta M. <jmdavis(a)fas.harvard.edu>
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Subject: SAVE THE DATES - Steven Chu, April 24, Colloquium | April 25, Lee Historical
Lecture in Physics
Steven Chu
William R. Kenan Jr. Professor
Professor of Molecular and Cellular Physiology
and of Energy Science and Engineering
Stanford University
1997 Nobel Prize in Physics
[cid:image001.jpg@01D96BB0.25AFBAB0]
Harvard Physics Colloquium
"Entropy, molecular motors, and non-thermal equilibrium statistical physics"
Monday, April 24, 2023, 4:30pm
(Colloquium Tea served in Jefferson 450 @ 3:30 PM – Please bring your own mug if you have
one.)
Jefferson 250, 17 Oxford Street, Cambridge, MA
and zoom (see the link below)
The transport of molecular cargos in neuronal cells is analyzed in the context of new
developments in entropy and statistical physics. Our development of very bright optical
probes enabled the long-term single tracking of molecular cargos in live neurons. The
number of active dynein motors transporting a cargo is found to switch stochastically from
one to five dynein motors during the long-range transport in neurons. Our probes allowed
the observation of individual molecular steps where the time between single steps is
controlled by two temperature-dependent rate constants. This finding suggests that two ATP
molecules are hydrolyzed sequentially during each dynein step.
The measured fluctuations can be described by a steady-state non-thermal equilibrium
temperature, Teff as high as 6× Tcell = 6×310 K, and inversely proportional to the number
of motors. Using the Fluctuation Theorem (proven in 1993) is consistent an “uncertainty
principle” limit, ΔQ ⋅ ϵ2 ≥ 2kBTeff, where ΔQ = Teff ΔS is the minimum heat entropy needed
to achieve an outcome with a given statistical precision. This theorem sets a lower limit
to the heat energy needed to achieve a given precision in any physical operation. In the
context of intercellular molecular transport, a smaller variance in the displacement of
the vesicle demands a greater expenditure of energy.
# # #
2023 Lee Historical Lecture in Physics
"A random walk into laser cooling, optical trapping and beyond"
Tuesday, April 25, 2023, 5:00pm
Jefferson 250, 17 Oxford Street, Cambridge, MA
and zoom (see the link below)
A personal perspective of how laser cooling and optical trapping of atoms and biomolecules
was developed. Emphasis will be given on how an elementary understanding of the physics at
an undergraduate physics level led to success in initial successes. Once the basic tools
of optical molasses and optical trapping were developed, more random walks into polymer
physics and biology will be described.
# # #
Steven Chu is Professor of Physics, Molecular and Cellular Physiology, and Energy Science
and Engineering at Stanford University.
He received the 1997 Nobel Prize in Physics for laser cooling and trapping of atoms. Other
contributions include the first optical tweezers manipulation of biomolecules, precision
atom interferometry based on optical pulses of light, and single molecule FRET of
biomolecules tethered to surfaces.
He is now developing and applying new methods in molecular biology and medical imaging,
materials science, and batteries.
Previously he was U.S. Secretary of Energy, where he began ARPA-E, the Energy Innovation
Hubs, and was tasked by President Obama to help BP stop the Macondo Oil spill. Previously,
he was director of Lawrence Berkeley National Laboratory and Professor of Physics and
Applied Physics at Stanford, and help initiate Bio-X, that linked the physical and
biological sciences with engineering and medicine. Before Stanford, he was a department
head at Bell Laboratories. He was past president of the American Association for the
Advancement of Science, a Senior Advisor to the Directors of the NIH and the NNSA. He
received an A.B. degree in mathematics and a B.S. degree in physics from the University of
Rochester, a Ph.D. in physics from the University of California, Berkeley, has 35 honorary
degrees, and is a member of the U.S. National Academy of Sciences and 8 foreign
academies.
# # #
David M. Lee Historical Lectures in Physics are sponsored by the Marvin and Annette Lee
Fund
# # #
Please click the link below to join the webinar:
https://harvard.zoom.us/j/92297706336?pwd=eHhqZUswNGliQXpOeVpoZFFsNHBFUT09
Passcode: 694953
Or One tap mobile :
US: +13017158592,,92297706336#,,,,*694953# or
+13052241968,,92297706336#,,,,*694953#
Or Telephone:
Dial(for higher quality, dial a number based on your current location):
US: +1 301 715 8592 or +1 305 224 1968 or +1 309 205 3325 or +1 312 626 6799
or +1 646 931 3860 or +1 929 436 2866 or +1 253 205 0468 or +1 253 215 8782 or +1 346
248 7799 or +1 360 209 5623 or +1 386 347 5053 or +1 507 473 4847 or +1 564 217 2000
or +1 669 444 9171 or +1 669 900 6833 or +1 689 278 1000 or +1 719 359 4580
Webinar ID: 922 9770 6336
Passcode: 694953
International numbers available:
https://harvard.zoom.us/u/adgkwO9yy
Or an H.323/SIP room system:
H.323:
162.255.37.11 (US West)
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115.114.131.7 (India Mumbai)
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Meeting ID: 922 9770 6336
Passcode: 694953
SIP: 92297706336(a)zoomcrc.com
Passcode: 694953
# # #
With any questions, please contact
Jolanta M. Davis, Administrator to the Chair of the Department of Physics, Prof. Efthimios
Kaxiras
(pronounced
Yo-lan-ta<https://forvo.com/word/jolanta/>)
Harvard University | Department of Physics | 17 Oxford St., Jefferson 352 | Cambridge, MA
02138
Tel.: 617-495-2866 | Fax: 617-495-0416 |
https://www.physics.harvard.edu/
In the office: Mondays, Tuesdays
Working remotely: Wednesdays, Thursdays, Fridays
Member of
HUCTW<https://huctw.org/send-email-harvard-leaders> (Harvard Union of
Clerical and Technical Workers)
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Profile<https://www.linkedin.com/in/jolantadavis/>
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