Hi all,
Tomorrow at 2:30 Dmitry will talk at group meeting. Title and abstract
below.
Best,
Ian
-----------------------
Speaker: Dmitry Zubarev
Title: Enantio-enrichment in Prebiotic Amino Acid Synthesis
Abstract:
The origin of biological homochirality is still a mystery. The earliest
reactions that create stereogenic bonds in prebiotically relevant reaction
networks are good suspects for chiral induction. I will talk about an
ongoing experimental and theoretical investigation of chiral induction in
the hydrolysis of aminonitrile precursors to proteinogenic amino acids
catalyzed by chiral ketones, aka Strecker reaction. The role of theory in
this effort is to reveal mechanistic underpinnings of prebiological
enantioselective organocatalysis. Computational analysis is also used to
motivate experiments via prediction of substrate/catalyst combinations with
high propensity to enantioenrichment.
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