Hi everyone,
Tomorrow's group meeting will be given by Dmitry. Please see below for the
title and abstract of his talk.
Jennifer
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Title
Search For A Perfect Leaving Group In Nucleic Acid Polymerization
Abstract
Non-enzymatic template-directed RNA replication is fundamental to the RNA
World model of the origin of life. The efficiency and accuracy of the
process still remain far from what is necessary for the integration with
protocell model. There are multiple problems that have to be resolved. One
of them is a requirement for the activation of the monomer units in order
to make polymerization thermodynamically favorable. Activated monomers,
however, experience degradation due to hydrolysis and cyclization. I will
discuss a recent effort in computational screening of the nucleophilic
leaving groups for non-enzymatic RNA oligomerization. The goal of the
screening is to identify the candidates that have more favorable kinetic
characteristics in the competing reactions of dimerization and hydrolysis
than currently used 2-methylimidazole.
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