Dear Group,
Pardon the frequent emails. This is a reminder about tomorrow's Theory
Seminar at 4:15pm in Naito 030 (Tue 9 Dec). Dr. Jingzhi Pu of the Karplus
Group will be presenting. His title and abstract are as follows:
*Coupling Mechanisms in F1-ATPase
F1-ATPase is the smallest rotary motor in biology. With ATP binding,
hydrolysis, and product release, the motor induces a torque on the central
shaft gamma-subunit, which rotates about 1000/sec in one direction. When an
applied torque rotates the gamma-subunit in the reverse direction, the motor
synthesizes ATP, its normal function in living cells. In this presentation,
we will discuss the progress of using a multiscale approach that combines
coarse-grained model, targeted molecular dynamics and free energy
simulations to elucidate how the rotary motion is achieved via intimate
coupling between the ligand binding/catalytic subunit conformations and the
gamma-subunit.
*
Our next seminar will be in January. I'll send out an annoucement after the
holiday break.
Thanks,
Anna
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