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Event Information:
Date : 2/14/2007
Start Time : 02:30 PM
End Time : 04:00 PM
Title : Modeling Neocortical Networks with Short-term Synaptic Plasticity (Misha
Tsodyks)
Description : COMPUTATIONAL NEUROSCIENCE COLLOQUIUM
Modeling Neocortical Networks with Short-term Synaptic Plasticity
Misha Tsodyks
Weizmann Institute
Wednesday, February 14, 2.30pm
Maxwell Dworkin 115
ABSTRACT
Recurrent connections in neocortical circuits exhibit pronounced activity-dependent
short-term plasticity--synaptic depression/facilitation--but the role it plays in
information processing is still not clear. Recent experiments indicate that synaptic
properties may systematically change when moving along the information stream from the
sensory areas towards the prefrontal cortex. In particular, it was found that connections
between pyramidal neurons in the prefrontal cortex are more diverse, with substantial
fraction of them exhibiting strong facilitation, as opposed to corresponding connections
in the sensory areas that are predominantly depressing. To uncover the potential
functional implications of these diverse properties, we analyzed two different recurrent
networks. In the first study, we describe the information processing via temporal neuronal
synchronization (which we call 'Population Spikes') in network with synaptic
depression. In particular, we constructed a neura
l network model of primary auditory cortex that responds to complex sounds with specific
spatio-temporal pattern of population spikes at different iso-frequency columns. In the
second study, we analyzed the attractor neural network model of persistent activity with
synaptic facilitation. Depending on the strength of synaptic facilitation, the network
exhibits qualitatively different regimes of convergence to persistent activity sate, from
fast irreversible transition with population spike, to slow reversible transition. We then
considered the attractor neural network of interacting sub-populations with different
synaptic properties, and observed an emerging new selectivity of the resulting persistent
state to the temporal profile of the triggering input.
Host: Leslie Valiant
Location : Maxwell Dworkin G115
URL :
Phone :
Calendar : Computer Science Colloquium Series
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