FYI….. MIT Special Biophysics Seminar Monday, November 20 @3:00pm in Duboc Room 4-331 Ashwin Gopinath<http://caltech.academia.edu/AshwinGopinath> Caltech DNA origami: The bridge from bottom to top Conventional top-down nanofabrication, over the last six decades, has enabled almost all the complex electronic, optical and micro-fluidic devices that form the foundation of our society. Parallel efforts, exploring bottom-up self-assembly processes, have also enabled design and synthesis of structures like quantum dots, carbon nanotubes and unique bio-molecules that possess technologically relevant proper- ties unachievable top-down. While both these approaches have independently matured, ongoing efforts to create “hybrid nanostructures” combining both strategies, has been fraught with technical challenges. The main roadblock is the absence of a scalable method to deterministically organize components built bottom-up within top-down nanofabricated structures. In this talk, I will first introduce a directed self-assembly technique that utilizes DNA origami1 as a molecular adaptor to modularly position, and orient, bottom-up nano-components (like quantum dots, light emitters and proteins) within top-down nanofabricated devices.2 I will then present experimental results demonstrating the utility of the technique to achieved absolute, arbitrarily scalable, control over the integration of discrete emitters inside optical devices.3,4 Finally, I conclude by presenting my vision of how DNA origami assisted modular bridge between top-down and bottom-up nanofabrication can enable a range of highly transformative, functional, devices. Specifically, I will discuss unpublished data demonstrating arrays of single-photon sources, platform for studying bio-chemical networks with discrete components and designs for using this technology for real-time highly-multiplexed protein quantification. Host: Mark Bathe Please post the attached .pdf poster to advertise the talk _______________________________________________ biophysics-seminar mailing list biophysics-seminar@mit.edu<mailto:biophysics-seminar@mit.edu> http://mailman.mit.edu/mailman/listinfo/biophysics-seminar