[Aspuru-Guzik group list] [IACS-events] IACS Seminar Friday, February 22: Boyce Griffith (NYU) on Multiphysics and Multiscale Modeling of Cardiac Dynamics

Date: Friday, February 22, 2013 Speaker: Boyce Griffith, Assistant Professor of Medicine and Mathematics, New York University Location: Maxwell-Dworkin G125, 33 Oxford Street, Cambridge, MA 02138 Time: Informal lunch with speaker, 12:30pm. Talk, 1:00pm. Title: Multiphysics and Multiscale Modeling of Cardiac Dynamics Abstract: The heart is a coupled electro-fluid-mechanical system. The contractions of the cardiac muscle are stimulated and coordinated by the electrophysiology of the heart; these contractions in turn affect the electrical function of the heart by altering the macroscopic conductivity of the tissue and by influencing stretch-activated transmembrane ion channels. In this talk, I will present mathematical models and adaptive numerical methods for describing cardiac mechanics, fluid dynamics, and electrophysiology, as well as applications of these models and methods to cardiac fluid-structure and electro-mechanical interaction. I will also describe novel models of cardiac electrophysiology that go beyond traditional macroscopic (tissue-scale) descriptions of cardiac electrical impulse propagation by explicitly incorporating details of the cellular microstructure into the model equations. Standard models of cardiac electrophysiology, such as the monodomain or bidomain equations, account for this cellular microstructure in only a homogenized or averaged sense, and we have demonstrated that such homogenized models yield incorrect results in certain pathophysiological parameter regimes. To obtain accurate model predictions in these parameter regimes without resorting to a fully cellular model, we have developed an adaptive multiscale model of cardiac conduction that locally deploys detailed cellular models only where needed, while employing the more efficient macroscale equations where those equations suffice. Speaker bio: Boyce Griffith is a computational scientist at New York University, where he is an Assistant Professor of Medicine and an affiliate faculty member of the Department of Mathematics at NYU's Courant Institute of Mathematical Sciences. His research focuses on the development and application of methods for simulating cardiac and cardiovascular dynamics, including the fluid dynamics of heart valves, electrical impulse propagation in cardiac muscle, and cardiac electromechanics. He is also the principal architect of the IBAMR software, a general-purpose open-source framework for simulating biological fluid-structure interaction used by a number of independent research groups around the world. Griffith received his BS in Computer Science and his BA in Mathematics and in Computational and Applied Mathematics from Rice University in 2000 and his PhD in Mathematics from the Courant Institute of Mathematical Sciences at New York University in 2005. He was a Courant Instructor in the Department of Mathematics at NYU from 2005--2006, was an American Heart Association Postdoctoral Fellow at NYU from 2008--2008, and has been a member of the faculty at NYU School of Medicine since Fall 2008. Visit http://iacs.seas.harvard.edu/events to subscribe to our Google calendar, manage your subscription to this mailing list, or access video and audio recordings of previous seminars. _______________________________________________ Iacs-events mailing list Iacs-events(a)seas.harvard.edu https://lists.seas.harvard.edu/mailman/listinfo/iacs-events