Date: Friday, February 22, 2013
Speaker: Boyce Griffith, Assistant Professor of Medicine and Mathematics, New York
University
Location: Maxwell-Dworkin G125, 33 Oxford Street, Cambridge, MA 02138
Time: Informal lunch with speaker, 12:30pm. Talk, 1:00pm.
Title: Multiphysics and Multiscale Modeling of Cardiac Dynamics
Abstract:
The heart is a coupled electro-fluid-mechanical system. The contractions of the cardiac
muscle are stimulated and coordinated by the electrophysiology of the heart; these
contractions in turn affect the electrical function of the heart by altering the
macroscopic conductivity of the tissue and by influencing stretch-activated transmembrane
ion channels. In this talk, I will present mathematical models and adaptive numerical
methods for describing cardiac mechanics, fluid dynamics, and electrophysiology, as well
as applications of these models and methods to cardiac fluid-structure and
electro-mechanical interaction. I will also describe novel models of cardiac
electrophysiology that go beyond traditional macroscopic (tissue-scale) descriptions of
cardiac electrical impulse propagation by explicitly incorporating details of the cellular
microstructure into the model equations. Standard models of cardiac electrophysiology,
such as the monodomain or bidomain equations, account for this cellular microstructure in
only a homogenized or averaged sense, and we have demonstrated that such homogenized
models yield incorrect results in certain pathophysiological parameter regimes. To obtain
accurate model predictions in these parameter regimes without resorting to a fully
cellular model, we have developed an adaptive multiscale model of cardiac conduction that
locally deploys detailed cellular models only where needed, while employing the more
efficient macroscale equations where those equations suffice.
Speaker bio:
Boyce Griffith is a computational scientist at New York University, where he is an
Assistant Professor of Medicine and an affiliate faculty member of the Department of
Mathematics at NYU's Courant Institute of Mathematical Sciences. His research focuses
on the development and application of methods for simulating cardiac and cardiovascular
dynamics, including the fluid dynamics of heart valves, electrical impulse propagation in
cardiac muscle, and cardiac electromechanics. He is also the principal architect of the
IBAMR software, a general-purpose open-source framework for simulating biological
fluid-structure interaction used by a number of independent research groups around the
world. Griffith received his BS in Computer Science and his BA in Mathematics and in
Computational and Applied Mathematics from Rice University in 2000 and his PhD in
Mathematics from the Courant Institute of Mathematical Sciences at New York University in
2005. He was a Courant Instructor in the Department of Mathematics at NYU from 2005--2006,
was an American Heart Association Postdoctoral Fellow at NYU from 2008--2008, and has been
a member of the faculty at NYU School of Medicine since Fall 2008.
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