---------- Forwarded message ----------
From: "Alan Aspuru-Guzik" <alan(a)aspuru.com>
Date: Mar 31, 2013 2:30 PM
Subject: [Aspuru-Guzik group list] Fwd: Molecular Movies with the SLAC
X-ray laser. GPCRs and Photosynthesis. April 19
To: <aspuru-list(a)lists.fas.harvard.edu>
--
Alan Aspuru-Guzik
Associate Professor of Chemistry and Chemical Biology
Harvard University
http://aspuru.chem.harvard.edu
Forwarded message:
*From:* John Spence <spence(a)asu.edu>
*To:* jacobsen(a)chemistry.harvard.edu <jacobsen(a)chemistry.harvard.edu>du>,
alan(a)aspuru.com <alan(a)aspuru.com>om>, cohen(a)chemistry.harvard.edu <
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*Cc:* David Bell <dcb(a)seas.harvard.edu>
*Date:* Sunday, March 31, 2013, 2:26:59 PM
*Subject:* Molecular Movies with the SLAC X-ray laser. GPCRs and
Photosynthesis. April 19
Dear Colleagues,
I've been asked to give a talk in Applied Physics on April 19, however
this biophysics project may also be relevant to people in your department.
I've be grateful if you would bring it to the attention of interested
students and postdocs.
regards and thanks,
John
Molecular movies from the first X-ray laser.
Harvard Applied Physics, April 19, 2013,
John C. H. Spence* Physics, ASU and LBNL.
spence(a)asu.edu
Snapshot X-ray diffraction from the first hard X-ray laser near
Stanford (the LCLS) has provided time-resolved atomic-resolution images of
the molecular machine in all green plants which splits water to create the
oxygen we breathe, and digests CO2. I'll describe the single-file
synchronized submicron droplet beam we use to run molecules across the
pulsed laser, and how we image protein molecules important in
disease (GPCRs, membrane proteins, 2D crystals, an enzyme drug target for
sleeping sickness), use femtosecond pulses to outrun radiation damage, and
unscramble orientational disorder from randomly oriented molecules in
solution without modeling, using angular correlation functions. I'll
describe how this coherent radiation provides new solutions to the phase
problem for nanocrystals.
The project has been ranked one of the top ten breakthroughs of 2012 by
Science journal.
*And many others - see our review (attached) Spence, Weierstall and
Chapman: Rev Mod Phys. 75, 102601 (2012).
A conference on X-ray lasers for biology will be held at the Royal Society
in London from October 14 - you are most welcome to attend.
Regent's Prof John C.H. Spence ASU Physics/LBNL
http://www.public.asu.edu/~jspence/
https://sites.google.com/a/lbl.gov/biology-with-fels/
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